This depends heavily on how they are getting fast healing. Some fast healing abilities have built in conditions that determine if it's active or not. If you have some way to stop those conditions then you stop the fast healing.
for example. a fire mephit only has it's fast healing while it's physically in contact with a fire source. If you throw a bucket of water on the source or bull rush it away from the source you shut off it's fast healing. At least until it's able to re-establish those conditions that trigger it's fast healing.
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I'm curious how someone is getting constant fast healing in the first place, since thats generally a pretty restricted ability.
regardless if they have super High AC rather than worrying about dealing with damage and the like just use things that target other defenses.
Alchemists throwing bombs to hit touch AC which is generally lower than regular AC.
Or utilize Combat maneuvers, since CMD is also usually lower than AC by a fair bit. Trip will hurt AC, disarm will make them ineffective, dirty trick will eat actions, and grapple can flat out take them out of the fight with a few decent rolls.
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Hmm, is this person playing a Skald by any chance? If so, preventing him from using his Perform skill will resolve the issue. Their fast healing only works while the rage song is ongoing. Grappling usually works for the movement based perform checks. If its singing or chanting, throw a smoke grenade or something that will cause them to start coughing. If they are incapable of making noise, they are effectively shut down as far as that goes (and their spells).
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Given how rapidly damage accumulates in Pathfinder, and how slowly Fast Healing removes that damage, I'm surprised this is an issue.
There are lots of ways to get at a foe (such as the PC in question) who has high AC. E.g. Suggestion above was to attack CMD with a combat maneuver.
I once GMd a bunch of weak goblinoids against a single strong Full Plate armored Fighter. Goblinoids eventually figured out they could not hit AC, so they changed to dogpile (aka grappling) tactics. This worked great (for the goblins), not so great for the PC. Fighter killed the first goblin to grapple via an AoO but didn't have Combat Reflexes. Not that it would have changed the outcome. Allies arrived just in time to save the prone-and-grappled PC from being knifed to death by ten grappling goblins.
How fast is this fast healing? I can't think of anything in the official rules that would make this an issue. Even if you allowed things to stack that shouldn't be stacking, the fast healing shouldn't be much of an issue.
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mundane solution: stab it for more than its fast healing value every turn
Give them enough bleed damage to counteract the fast healing
He's a 16th-level Unchained Monk with 30 Wisdom (natural 20, boosted it 4 with levels, has a +6 item) and the Saint template from Book of Exalted Deeds, which grants his Wisdom as an insight bonus to AC/CMD. His equipment consists mainly of defensive items; +5 deflection, bracers +6, he has Barkskin ki power for +5 more, his Dex is 22.
His base AC is 52. He has ways of getting it closer to 60.
The Saint template gave him Fast Healing 10.
I'm tired of the game not giving Martials more abilities to overcome things without the use of magic. I was hoping there was a feat or even an alchemical item one could use on their weapon so that a hit could nullify the fast healing.
he has 3.5 shenanigans going on that explains things quite a bit. At that level you might be able to hurt him if you throw a bunch of cr 23+ monsters at him. 3.5 has some really unbalanced options making it hard to counter in a reasonable manner.
With that much third party, just make up a new magical weapon: ugly wounds. It would negate natural healing and effects that work like natural healing like fast healing.
I'm tired of the game not giving Martials more abilities to overcome things without the use of magic. I was hoping there was a feat or even an alchemical item one could use on their weapon so that a hit could nullify the fast healing.
Uh, if 3.5 material is being used, you have a whole other issue to deal with. But, mostly, you are dealing with a hefty Supernatural and Magical template, which is going to require more of the same to overcome... easily. If magic boosts his AC up that high, you will need magic to counter it.
As for overcoming the Monk (Saint), one of the other posters already recommended how to handle the issue. Drown him, or otherwise suffocate them.
The simplest mundane way to negate fast healing is to kill the creature with fast healing. : /
If your PC has a really high AC, keep in mind three things:
1. If it's anything past the first couple of levels, they probably invested a lot of character resources into being difficult to kill and should thus enjoy the benefits. There's always swarms, traps, maneuvers, alchemical items targeting touch AC, and really strong enemies with high attack and damage bonuses to occasionally threaten the tank.
2. Those are resources that didn't go into making the PC a walking problem solver. They won't hit as hard or have as many plot coupons as a character who didn't spend it all on mundane survivability. In extreme cases, intelligent opponents might figure out to simply ignore such characters until they've dealt with the rest of the party.
3. At higher levels, AC becomes much less relevant, as it costs more and more to continue to increase while attack bonuses go up for free.
TL;DR: Don't worry about it.
Edit: Wait, this is a 16th-level monk with 3.5 material? Why on earth are you limiting yourself to mundane means?
Bleeding Critical on a crit-fishing martial. It doesn't stop the fast healing, but it would offset the amount he heals /shrug.
His base AC is 52. He has ways of getting it closer to 60.
The Saint template gave him Fast Healing 10.
Any creature who can hit AC 52 (which even the Tarrasque would struggle with), let alone AC 60, should be capable of doing at least 100 points of damage per round. It doesn't sound like the Fast Healing is the main problem here.
Or accept that at an effective player level of 18 (with crazy 3.5. stuff), you need non-mundane enemies to challenge the PCs. D&D was never designed for mundane high-level combat, and Pathfinder didn't change that.