He's gonna be The Littlest Chevalier by the time we are done. ;)
On an off note, no matter how many times I was told Bethil was a female, I kept using masculine pronouns D:
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How you our poor, comrade!
Aw, Ary! Your first follower is Tiny-sized! I bet his hands can fit into little places... good for thievin'...
You know, with a continual flame Iridescent Spindle ioun stone, he could hang out in Ary's bag of holding and maintain our inventory. Just install some shelves for storage and a bed so he can sleep. Throw in a couple books every now and again.
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Safely back after a delayed flight!
I'm glad! Welcome back :)
Sorry, I was gonna get a post up today, but work called me in because my coworker's dad fell. :(
The father is fine. Catching up, now.
I'm glad they're fine :) No problem!
Sorry about the slowness, guys. I'm pretty sick right now, but I'm starting to feel a little better.
That's good at least. I hope it wasn't anything serious.
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I dunno about the rest of the party, but I forgive you under no circumstances.
Tested positive for the flu today :( Sorry I've been absent, been feeling pretty terribad.
Yikes, sorry to hear that. :(
Take my energy and get better soon! ༼ つ ◕_◕ ༽つ
That sucks, get better quickly!
I'm with Xander. How dare you get the flu!?
Feel better quickly. :3
Still sick :( will post tomorrow
There! Sorry about the delay, I've been pretty dead these past few days :( Thanks for your patience!!!
Really happy we were able to get Isilme started on anti-virals early, she's pretty much evaded the whole thing :)
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I finally thought of a spell for Xanderghul to research.
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The Curse of Eternal Wasting
illusion [curse, phantasm] 3
Range touch
Duration permanent
This spell makes the target feel like they have to poop all the time, even when they don't. It causes the target to be sickened. In addition, one per hour the target must spend 5 minutes attempting to poop. If they do not, the penalty for the sickened condition increases to -3 for that hour.
The Curse of Eternal Wasting can be removed with remove curse or break enchantment. Foes that do not have to poop (like outsiders or plants) take no penalties from this spell but are still affected by it, as are foes wearing a ring of sustenance or a similar item. If a foe that is not affected by this spell eats, they are affected by this spell for 1 day.
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Bonus points if I secret page the spell's effects to make it seem like a really potent curse spell that causes an enemy to waste away. Somebody learns it and casts it vengefully on an enemy only to discover that it just makes them really want to poop.
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Alternate name: Xanderghul’s revenge. ;P
And then he can work it into magic item form: A glass that curses any who drink from it with Xanderghul's Revenge unless the beverage is alcoholic.
No response for Ary :(
Sorry Ary, I let her post some, but then she was tired so I made her go to bed ;p
Alrighty
I've been having a work week from hell this week, so I'm not sure of my post rates or abilities to post for a bit. At this rate, I'll have about 70 hours put in by the end of Sunday, so, Ary's ready to turn in. Keep Watch on herself and Isilme again.
Hope you survive Ary! :O
You can do it, Ary :)
Go Ary, go!
Also, are you feeling better Kiora?
The flu really sucks. I don't recommend it.
I am feeling a lot better.... finally!
Glad you've finally recovered :)
Congrats on your wellness.
Yeah, just lots of hours and no coworker, and covering for third shift. So waaay overworked. Glad you're better. :)
Back to work today, will be unavailable for the rest of the night most likely. Have a good Friday!
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Good news! I found my picture of Ellie. Apparently, I downloaded it. :P
So pretty! :O
Elliemajigger "Ellie" Bishop is now canon. :P
Kiora, I am currently teaching a psychology course named Hormones, Drugs, and Behaviour. Basically, I will be talking about the basic action mechanisms of the most well known psychoactive drugs. And, I had a question. How are lipid soluble drugs carried to their site of effect? Somehow, from what I remember of chemistry, I would expect them to either stick together in small lipid bubbles or simply get lost into cell membranes. However, I could not find a satisfactory answer to these questions.
Nice Ary, really cool choice of portrait for Ellie :)
Hinagiku - that sounds awesome :) I'd totally take that class, haha.
As for lipophilic drugs -
Lipophilic drugs don't form lipid bubbles because molecules that do so are always strongly amphiphilic. Amphiphilic molecules possess both polar (hydrophilic) and nonpolar (lipophilic) portions - they will aggregate in a way in a solution where the hydrophilic ends will face the water molecules to form hydrogen bonds while the lipophilic molecules will face inwards, forming a sphere. (AKA how cell membranes work, as well as soap bubbles).
Strongly amphiphilic drugs are relatively rare. Ones of interest to you are the tricyclic antidepressants, fluoxetine, and the psychoactive phenothiazines (very large class, includes chlorpromazine and fluphenazine). These drugs actually do get "stuck" inside of plasma membranes where they can cause Phospholipidosis - a condition in which the drugs accumulate within lysosomal membranes and impair their function.
Lipophilic drugs will prefer to interface with lipids, but because they themselves are so small compared to the water in our bodies, and also because we really lack large contiguous quantities of oil in our bodies for them to get "stuck", they just kind of move around our bodies via the bloodstream like hydrophilic drugs do. The main difference between lipophilic and hydrophilic drugs is that because lipophilic drugs can readily dissolve across the phospholipid membrane, lipophilic drugs will become evenly distributed across our tissues. If you visualize the human body as essentially a large container of water, that is segregated into compartments using thin fatty membranes, it is easy to understand that hydrophilic molecules will become trapped in the water compartments, while lipophilic molecules can simply "walk through the walls" of the fatty membranes to pretty much wherever in the body. Of interest to your class, of course, is the fact that lipophilic drugs can passively dissolve across the blood-brain-barrier. Additionally, because lipophilic drugs can move through the tissues of the bladder and the intestine, they must be "trapped" there for excretion from the body. For this reason, our body is equipped with a robust number of enzymes (known as cytochrome P450 enzymes) that essentially exist to convert lipophilic drugs into hydrophilic ones, thus preventing their "escape" from our urine.
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Great, thanks for the answer! Somehow, I had gotten the impression that lipophilic necessarily meant they were also amphiphilic.
Yep, talked about the BBB last class. And, that's when I had to explain that lipophilic drugs can pass that barrier. And, that's when I realized I had no idea how a drugs traveled in the blood stream all the way to the brain! Luckily, that's not something I want to delve in because there is so little time to talk about so much in the course.
I work today, so I will be unavailable to post until this evening. Have a good day.
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Hey guys! Let's sneak across Drezen to the complete opposite side. It says they have a haunted vault. I bet it's full of epic lootz and we totally won't have a friend stolen by a dragon on the way into it!
Spell idea: Permanently switch two of your ability scores.
There's a spell that lets you switch drain from a physical stat to the corresponding mental stat or vice versa. Interesting way to deal with drain or damage in the short term.
Switching ability scores permanently would be a hard spell to figure out what level to place it at. It obviously is possible with wish, but is the spell really useful enough to spend a full wish on? How about a limited wish?
I guess it'd depend upon the intended use, which would be a late-life respec maybe? Can't imagine what else you could use it for. Ironically, a short-term stat swap spell would be far more powerful and useful.
Yeah, I suppose a temporary one would be useful but it wouldn't make as much sense to me.
Actually, one of the "respec" spells that I really like is *psychic reformation*, from DSP psionics. The mythic version allows you to instantly re-train everything about your character.
I am going to work pretty late today and will be unavailable to post. See you tomorrow!
Hey Val, feel free to intimidate the hell out of the guy. Maybe we can get him to give us the golem codes and a full tour of the tower. :o
Plan: We prepare the army to march in the morning. The group heads to where it currently is, and Val and I assume our disguises again. This time Ehren will disguise himself as a rat and tag along.
We 'visit' again, this time sabotaging their base, first by disabling the gong, and second by trapping Arta in her room with magic. Finally we trick Mokug into heading into an ambush. With Arta trapped and Mokug out, the cultists will have no leader. That just leaves killing the Shantak and clearing out ~50 cultists, which we could easily do with our group plus a select group from the army of maybe a dozen or so people.
If we play our cards right, we could theoretically take the tower with next to no casualties and no warning going out. Since the golems have a short range of operation, we can very likely ignore them and treat this as a commando mission.
Once we have taken the tower, it will be trivial to open the gate and allow our forces in. At that point we can consider going to the other towers to disable their gongs as well. Doing so would limit them to sending messages via teleporting demons, which seems like they are limited in at the moment.
I like this plan! But, I have two worries:
Is it possible that the horns that the guards have might be heard by the other towers?
Also, won't sentinels on the other towers be able to sport our army crossing the gates?
Yeah, I think you're forgetting the horns again :P
All the folks on top of the tower have horns, so we have to be super careful there.
We definitely need to hit before daybreak, because most enemies can only see 60 feet or so. The incoming storm is another concern. Either we press forward now and try to wreak as much havoc as we can, or we find someplace else to bed down for the night. I'm guessing a survival check would help us find a place to bed down, but I'm also pretty sure such a cave would be taken by GIANT MYRMECOLEONS.
What? Never.
I have the impression that the horns are more of a short distance alert for those stationed at this tower, while the gong is what they use to alert the other towers. Otherwise it'd be a bit redundant - hard to say, though.
As far as the other towers go, if we can't see them, then it stands to reason that they can't see us. Hopefully. :P
I think taking the tower by commando action is probably our best bet. Getting inside the city territory before they know what's happening can be useful, though we'll have to be careful to watch for forces trying to fall on us from the side or behind as we push forward.
We also need to make sure we deal with Hildebrand to make sure no one is trying to free Arta.