We recently had our first session run by a DM I’d never played with before. I was surprised to find that he house rules that all “out of combat” healing is basically maximized (like Maximize Spell). This applies even to Channel Energy, which made even our 1st level Cleric’s channels pretty great. I kind of look forward to not needing to roll so many d8s and track lots of wand charges in that game. I guess I might be able to look forward to the same in PF2E though I might also need to be more careful about recklessly taking damage (I'm already pretty carteful with most PCs)
I’m not sure yet if PF2E will really have a built in assumption that you enter a lot of fights without full HP, but if so maybe that would help some DMs limit their tendency to try to make every fight a deadly challenge. I guess it could also just mean that experienced players won’t lecture newer ones about how inefficient it is to buy wands of higher level Cure spells. It seems like you might get enough Resonance to heal yourself pretty well as long as you have appropriately leveled wands. I guess that could be reduced by the magic items you have, but presumably they’d help you do better in fights and take less damage to begin with.
Since potions are going to be limited by Resonance too I hope they’re a little more effective than they are now. It already often doesn’t seem worth buying and using them in 1E beyond the lowest levels or to have certain utility spells available.