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The only people you really need to get rid of somehow are the WotR PCs, who are just an order of magnitude more powerful than all the rest.
While they are by far the most powerful, that power is itself a way of putting them "on a leash." I treat Mythic as being a low grade of divine power and thus something that can generate active divine responses to proactive activities.
They do get a pass on things which are in their 'mortal concerns'. So the WotR PCs can deal with the leftover problems of the Worldwound, but if they head off to stomp an issue flat in Taldor then some demon lord might just play an "I'm just responding in kind," card and send forces to counter them. This also gives Mythic characters a reason to head out from the material plane to places where they will have more freedom of action.
Tar-Baphon gets away with things partly because "restore my empire, seek godhood and continue my fight against Aroden and his legacy," are his mortal concerns. He also likely doesn't really care if he sets off a spiral of ever increasing interventions, (he might even want the resultant chaos).