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On a small scale, I changed Yamasoth to be a Great Old One and the Qlippoth to be his spawn, instead of being proto-demons. I did this because one of my players is uncomfortable with a lot of demons or devils in the game. The occasional fight or reference is fine, but this was going to be a half-an-adventure length dungeon centered around Qlippoth. And the campaign was going to have more about Old Ones stuff anyway so it made sense.
On a larger scale, My friends and I have run about half a dozen APs and have been keeping a persistent world to reflect what has happened in the APs. Most famously, Karzoug won at the end of Rise of the Runelords, and Cheliax annexed the Shackles. We’re playing Shattered Star now as a response to Karzoug winning and one player is an apprentice of my character from the Wrath of the Righteous campaign we played.