I like to kick around the idea of living in an Emerging Tippyverse rather than a full blown functional one (which is likely to be static and boring).
In an Emerging Tippyverse, the powers that be are discovering all these cool neat ideas of things they can do with magic (think Renaissance, Industrial Revolution, etc). Old paradigms are going to shift or be rendered outright obsolete. Players themselves have an opportunity to put their own Tippy-mark on things too.
Some leaders and countries will catch on to what's happening, the slower ones, well - what happens there may present the seeds for adventures. Old ways of diplomacy will need to give way to newer ideas (like Mutual Assured Destruction). Intricate webs of diplomacy not unlike Europe during Bismarck's time may arise between countries and city-states.
Consider if just a few countries get launched up the Tippyverse development curve - say, Cheliax, Andoran, something that emerges from the River Kingdoms (and takes out Brevoy), Absalom and a couple of regional powers out to the East? Or maybe some of the Eastern cultures fail to "get it" and we have a modern Absalom encountering an antiquated Qadira (or whatever).
I think if presented in the right time-frame/context, you can have a blast with the Tippyverse concept. Though when you are done, Golarion is going to need some serious Aboleth/Inevitable intervention to blast everyone back to the stone age (and start anew!).