
Fuzzypaws |

If the spell has a somatic component, you will have to drop a hand off the weapon to cast, even if you don't need a hand for your material/focus component. Dropping a hand is free, buuuut adding a hand back to the weapon to regrip it for 2H use takes an action for some reason. So you can attack and cast just fine, but won't be able to attack again until you burn an action to wield the weapon, as if you'd dropped it on the floor or something and had to pick it up.

Draco18s |

If the spell has a somatic component, you will have to drop a hand off the weapon to cast, even if you don't need a hand for your material/focus component. Dropping a hand is free, buuuut adding a hand back to the weapon to regrip it for 2H use takes an action for some reason. So you can attack and cast just fine, but won't be able to attack again until you burn an action to wield the weapon, as if you'd dropped it on the floor or something and had to pick it up.
Almost.
SOMATIC CASTING
If you’re a cleric Casting a Spell from the divine tradition while
holding a divine focus (such as a religious symbol or text), you
don’t have to have a free hand to take this action, and you can
touch the target with the focus instead.

Atalius |

As an extension to the above: you have 3 actions on your turn, you can spend them however you want. With your weapon as your symbol you don't even have to spend actions swapping over to count for the somatic casting.
Just remember that spell attacks are subject to, and cause, multi-attack penalty.
I was not aware of this. So if I were to use a spell or spell power which involves a touch attack for example, and then used my weapon immediately after it would occur the -5 penalty to the attack roll and vice versa?

CommanderCoyler |
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Correct, spells that have attack rolls have the 'attack' trait. Spells that only have attack rolls on certain modes of the spell, such as Heal/Harm gain the trait when used in that way.
This ability grants an attack. For each attack you make beyond the frst on your turn, you take a multiple attack penalty (see page 305).

Draco18s |

I was not aware of this. So if I were to use a spell or spell power which involves a touch attack for example, and then used my weapon immediately after it would occur the -5 penalty to the attack roll and vice versa?
Correct, spells that have attack rolls have the 'attack' trait. Spells that only have attack rolls on certain modes of the spell, such as Heal/Harm gain the trait when used in that way.
Note that Heal and Harm don't actually say that, but that is the (correct) interpretation. It was clarified in this thread.