
John Murdock |
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For each negative level a creature has, it takes a cumulative –1 penalty on all ability checks, attack rolls, combat maneuver checks, Combat Maneuver Defense, saving throws, and skill checks. In addition, the creature reduces its current and total hit points by 5 for each negative level it possesses. The creature is also treated as one level lower for the purpose of level-dependent variables (such as spellcasting) for each negative level possessed. Spellcasters do not lose any prepared spells or slots as a result of negative levels. If a creature’s negative levels equal or exceed its total Hit Dice, it dies.
enervation is a pretty good spell to debuff enemies who are not immune to level drain, each one will make them weaker until they die from it or they are too weak to resist you

John Murdock |
Sweet gotcha! At the higher levels is there a better version of Enervate? Or could one just use Heighten Spell on it?
there's orb of the void a 8th level spell and like rathendar say also energy drain a 9th level spell, and the beauty of those 2 spell is that if you fail your save 24 hours later they are permanent unlike enervation which is temporary and only last for 1 hour per caster lvl (max 15H)