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So, today, after the Giant Centipede fight the party were trying to stop the poor poisoned bear from dying.
Characters kept making Treat Poison checks to get that +2 bonus. ESPECIALLY after the one critical failure.
On the one hand, I have little problem with poison being pretty easy to deal with outside of combat.
On the other hand, the image of 3 different characters frantically trying to deal with one poor bears poison each round (NINE treat poison attempts) seemed hilarious and very, very, very silly :-).
I kinda think that the -5 to subsequent attacks should also apply to things like medicine checks.