Here's a confluence of odd rules that could make for an interesting scene.
The Catch Off-Guard feat says:
You do not suffer any penalties for using an improvised melee weapon. Unarmed opponents are flatfooted against any attacks you make with an improvised melee weapon.
And the entry for the miner's pick says:
If a miner’s pick is used in combat, treat it as a two-handed improvised weapon that deals piercing damage equal to that of a heavy pick of its size.
So, at least by RAW, you could wander around with a miner's pick, gain the advantages of using a two-handed pick, and essentially treat every unarmed opponent as flat-footed.
Of course, you'd have to be a raving psycho to gain any real advantage from this, roaming the streets with a big pick and basically swinging it at unarmed folks. And your GM would have to ignore the very real possibility that bystanders may notice you swinging the thing at people and technically not be able to be caught flat-footed, but still -- there it is.
Any other odd combos of feats and weapons that create similarly surreal situations?
Add Improved Disarm...do that on your first attack and then the rest they are flatfooted. Add levels in Rogue/Ninja/Vivisectionist/etc... to up your damage output.
Oh no, it's the Mysterious Murder-Miner of Molthune! Every man for himself!
On the other hand there is a trait for +2 to hit (equals two times weapon focus) for improvised weapons.
And, it doesn't work on Monks as they count as armed. Or even people with spiked gauntlets. Or a shield.
Its really only useful against normal NPCs that don't ever expect to be in combat or maybe in a surprise round.
Not quite sure what benefit is being derived from the miner's pick. It just does 1d6 damage (20/x2). No different than picking up a razor sharp chair leg...