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I've recently finished GMing this AP, and my PC faced the last encounter with only 2 mythic tiers (I gave them one at the end of book 1, and one after the fight with the chimera in book 2).
I've balanced that a bit by removing about half of the "boss" lackeys, but otherwise, didn't adjust the "boss" sheet. The combat went on for about 5 rounds. It was difficult, yes, but they managed to win in the end.
And I think I need to point out that, barring the last 2 fights of the AP, my PCs totaly wrecked the opposition from the middle of book 2 to the 1st half of book 6 with only 2 mythic tiers (taking into acount that i've heavily beefed said opposition).
Honestly, the only use I see for the mythic rules are the mythic monsters : they are way less broken than PCs/NPCs with mythic tiers and can be used as tough - but still beatable - opposition.