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1)Never fudge numbers
Correction: Fudge numbers freely, but never let the players know that ou're doing so. RPGs, even Pathfinder, are not a competition, the are about the story. However, if they know you're fudging dice to keep their characters alive, their victory will feel hollow, while if they know ou're fudging dice against them, they will feel they have no chance and give up in frustration.
2)If a player rolls multiple natural 20s in a row consume the dice to gain its power.
Please don't do this. It'll play hell on your digestion.
I think my best advice is to pay a lot of attention to your players, and try to find out what works for them and what don't.
Groups are different, and therefore how to be a good DM for a given group will differ.