Before the game launches lets come up with some broken concepts that a space fantasy setting could have so that the dev's can prevent them from happening or fix them for balance.
Would a multi armed, multi pistol wielding character with rapid fire and two weapon fighting be too much? In a technological setting guns would need to be reloaded less often then missle weapons currently do.
4 pistols on a 4 armed race, rapid shot, two weapon fighting and dex loading could = 6 attacks at level 1 from 4 weapons? Evem assuming only 10 rounds per pistol careful shot rotation could mean firing for 5 or 6 rounds at full rate without needing to reload.
Even worse at higher level when the feats and BAB advances.
What potentially broken stuff can you come up with?
Monofilament crossbows that can decapitate an enemy at range.
If there's a spell/power which can animate a gun I could see some caster surrounded by guns. Fie on your physical handedness limits!
And then some tech guy sends in twice as many drones to deal with him.