
The 8th Dwarf |
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I have been playing XCom Enemy within it is brilliant and the background is excellent source for a campaign. The game, genetics, cybernetics, aliens, agents, new enemy faction (humans who want to use alien tech to rule the world).
Normally if I was going to run this as a RPG I would use GURPS, but I think Shadowrun would fit better.

jemstone |

Cyberpunk 2020/Interlock. The combat (as that's the primary focus of X-Com, let's face it) is solid and deadly. Very deadly. Mostly Class-Free character system, solid rules for armor (including staged penetration mechanics), cybernetics, and psychics can be folded in without much trouble at all.
I actually have rules for an X-Com style game using that system around here somewhere, I think. Lemme see if they survived the Great Data Crash of 2012.

The 8th Dwarf |
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This is the basic idea for my pitch:
I am not going to tell the players that it's XCom.
How would you guys like to play a modern day slightly supernatural game. I would like you to think of a character concept that would get you out and about, like a field archaeologist, CDC field scientist, A doctor from medicine sans frontiers, military, smuggler, I would alow people to be slightly psychic - suggestion, hunches and so on.
Then if I had time I would do a troop (one person playing their character and the others playing NPCs) style recruitment into XCom scenerio for each of the characters. Minimising the Alien involvement - hinting at a threat to humanity but from an unknown and "supernatural" force.
Slowly I would dripfeed the aliens and the set up of XCom. They would become an investigative team rather than a first response unit.

BillyGoat |
My choices (best to worst) would be...
New World of Darkness (with Dogs of War, Armory, and perhaps even Hunter when they're more powerful, as supplementals)
d20 Modern/Future
Shadowrun 5th Edition
I rank Shadowrun as the weakest contender because it both requires the most modification from it's core assumptions (drop extra races, avoid cyber/bio at start of play) and it tips your hand that you're going somewhere crazy with it.

jemstone |

It would appear that the Cyberpunk 2020 X-Com ruleset I built a while back did, in fact, fall prey to the Great Data Crash of 2012. Which is a shame, considering that you can use out-of-the-book weapons for nearly every piece of armament in any X-Com game (up to and including Blaster Launchers).
So, I can be of no help in that regard, I'm afraid.
Personally, I'd use GURPS for this sort of game. GURPS handles a wide-range of skills and variances in Tech Level, and can be scaled in power level with relative ease.
(GURPS falls down if you try to use it for 4-color super heroes, but is otherwise very flexible).
Come now. As we've seen, no one actually plays GURPS

Rathendar |
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It would appear that the Cyberpunk 2020 X-Com ruleset I built a while back did, in fact, fall prey to the Great Data Crash of 2012. Which is a shame, considering that you can use out-of-the-book weapons for nearly every piece of armament in any X-Com game (up to and including Blaster Launchers).
So, I can be of no help in that regard, I'm afraid.
** spoiler omitted **
Your spoiler did make me laugh, FWIW. ;)

Spastic Puma |

I created a Starcraft d20 campaign and it worked brilliantly. I created 4 characters to form a tactical squad of men and the players had to pick which one they were.
I looooooved the burst fire rules from Dragonstar. They worked so well and I got tons of compliments on how smooth they played in with the system. Basically you roll to hit once and for every 5 you exceed the target's AC, you get another hit (up to the amount of shots bursted).
As a big fan of XCOM I would recommend these burst fire rules to you. Look into Dragonstar's autofire rules as well.