
Natural 1s |

I'm building half-elf investigator with empiricist archetype. So he will not get Poison Lore and Poison Resistance (basically poison immunity).
Should I swap Elven Immunities with Thinblood Resilience to mitigate his weak fortitude progression?
(I will also get Dual Minded alternate racial trait to boost will save).

Jaunt |
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Diseases are a nonissue, unless you're playing Mummy's Mask or something. They're slow and you can fix them out of combat.
Poison is a bit scarier, but like I said, it's usually just stat damage. Some lesser resto and you're as good as new. It also generally requires you to be hit (thus, making AC a pseudo-save) where will saves you generally just get targeted
Delay Poison basically stops poison for the length of the adventure. It's a level 2 spell. Cure Disease is level 3. Lesser Resto fixes the damage the disease does, and also is level 2. If you want to stop enchantment schools? Mindblank comes online at 8th. Prot X will give you a second save to suppress the mind effect, but that's better for people who've got good will saves already.