A strange sickness afflicts the frontier settlement of Holver's Ferry, threatening to overwhelm its citizens with an alien madness. Already the town has nearly torn itself apart, and the local sheriff is missing. When the PCs brave the surrounding wilderness as the village's latest newcomers, the beleaguered townsfolk desperately turn to them for assistance. But can these erstwhile heroes trace the diseased carrier to long-abandoned Arvarenhode Manor and solve the mystery before they, too, succumb to the Assimilation Strain? Designed as a prequel for the upcoming Legendary Planet Adventure Path by Legendary Games, or as a standalone module to introduce off-world concepts to an existing campaign setting, "The Assimilation Strain" is a 1st level adventure for 4-6 characters.