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Area 20-ft.-radius spread centered on you
As a spread that's going to target an intersection and.. well. Hit you. Is there some general rule about spells not hitting you when they're centered on you or is anyone casting this spell going to be hurt as much as the other team ?
Synaptic pulse is going to hit you and any of your allies that are in the area. There's no general rule, so unless the spell description makes an exception it's really no different than casting explosive blast centered on a grid intersection next to you when it comes to who is affected. Unfortunately mystics do not have an option equivalent to the technomancer's Selective Targeting hack (yet).
If we're talking ridiculously high levels the vanguard Exclusion Zone discipline can be used with anything, regardless of class. But that requires 10 vanguard levels.

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Realizing that I am talking about something that is going to be somewhat dependent on a character's build, dependent on what enemies you are facing, and very dependent on your personal opinions about certain conditions...
Hitting yourself with synaptic pulse might not be that bad, even if you fail the save.
Effects that last a certain number of rounds end just before the same initiative count on which they began. Thus, if a spell with a duration of 1 round is cast on initiative count 14, it ends just before initiative count 14 on the following round.
If you cast synaptic pulse after you have moved, the worst you are doing is costing yourself a reaction and making yourself flat-footed for a round. You will still get your full round of actions on your next initiative count. However any affected enemies are losing their whole turn.
Greater synaptic pulse, on the other hand, could really suck...

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You also drop everything, either while surrounded by the enemy or surrounded by stunned party members looking at you funny..
Like I said, it's going to be build dependent. If your character plans on casting synaptic pulse, you're either going to be careful about not holding anything important or investing in one of the many options to not lose the item when you drop it.
Obviously the spell would be "better" (from the point of view of the caster) if the caster was immune. But the effects on a fail are relatively minor to the caster who knows what he is doing.