Okay lets talk DRUGS: You ingest some pesh and willing fail the save so you get the positive effect for an hour. Then, since you failed your save, you take the negative effects and move down on the Strength poison track to Weakened.
Then what? There isn't any frequency on drugs, so how do you get off the Strength Poison track? When do you make your next save?
If you take another dose, do you move even further down the track? Meaning you die after 5 doses?
Drugs are a special kind of poison that grant a beneficial effect right
away but also move the user a single step down the associated
poison track. However, the user doesn’t lose Hit Points, even if the
drug functions as a Constitution poison. Taking a drug also exposes
the user to the addiction disease (see page 418), with a DC that
depends on how addictive the drug is. If a character is dosed with
a drug against his will, he can attempt a Fortitude save against the
drug’s DC. If he succeeds, this negates both the drug’s beneficial
and negative effects, as well the chance for addiction. Immunity to
poison or a similar effect prevents a character from experiencing
the drug’s beneficial effects, and removing or suppressing a drug’s
negative effects with restorative spells also cancels the benefits.
If you take Transdimensional Pesh, you will move down the Dexterity and Wisdom tracks, but not the Strength track, per the Transdimensional Pesh block on page 419. You will also have to roll against being exposed to the physical addiction disease, at DC 20, per the Addiction disease rules.
There is no next save. You get off the tracks by being treated with Medicine, and you will die after 5 doses if not treated and you keep taking it willingly.
Once you stop taking it, and the duration ends, the effect wears off, but you're left in the point on the track you were:
Poisons and drugs work differently—fulfilling the cure condition (or reaching the end of a poison’s duration) removes a poison from the victim’s system, but she remains at the same step on the track and recovers gradually. For every day of bed rest (or two nights of normal rest), a victim moves one step toward healthy. This rate of recovery is doubled by successful Medicine checks (see Long-Term Care), though tenacious poisons might require a longer recovery period.
If the drug is addictive, you also have the chance of getting the addiction disease and progressing down that track separately.
Once you stop taking it, and the duration ends, the effect wears off, but you're left in the point on the track you were:
Poisons and drugs work differently—fulfilling the cure condition (or reaching the end of a poison’s duration) removes a poison from the victim’s system, but she remains at the same step on the track and recovers gradually. For every day of bed rest (or two nights of normal rest), a victim moves one step toward healthy. This rate of recovery is doubled by successful Medicine checks (see Long-Term Care), though tenacious poisons might require a longer recovery period.If the drug is addictive, you also have the chance of getting the addiction disease and progressing down that track separately.
Alright, so you do recover over time. Good, it would have been absolutely stupid otherwise.