Drejk |
Should be workable. However, it would require you to change Runelord into giant himself unless you want to rewrite some of the Xen'drik history.
Or maybe another take: Thassilon could be empire build on the ruins of the giants by some of the left-behind elves (drow or otherwise) that took control over some small area of the fallen giant empire and learned how to use dragonshards and runes imbued with magic to bind scions of the giant empire into their service.