My campaign starts tomorrow, and one of my players has another dnd group that will be starting serpents skull campaign shortly after us (week or 2). The other game will surpass us as they meet more frequently and play longer sessions.
Im not worried about the player bringing out of character knowledge into the game and destroying it. What i am concerned about is that they will be holding themselves back since they know whats in store.
Does this campaign have alot of plot twists and intrique?
I've only read the first two books, but I gather the two games could be a good deal different; which faction the PCs side with, for instance, could change a great deal. And depending on the GM, they may add, subtract, or change even more.
I don't know about plot twists in the overall AP, but the faction aspect alone could be interesting for someone playing in two concurrent campaigns.
There is a fair bit of "sandbox" aspects to the campaign. I have read all six adventures, and I agree with ChrisO that it is not likely that there will be any problems as there as so many variables in the campaign and very few plot twists.
The players likely already know the main plot twist, that the adventure will end with serpentfolk.