Don't know if any of you guys read Something Awful.com, but they have a humorous gaming podcast called "The Barbarian's Dojo."
I downloaded them and am enjoying them quite a bit. This dude basically rambles about gaming (mostly D&D), video games, movies, fantasy art, etc. It's not too serious but good for a listen all the same. I recommend the Halloween episode, and the Sexiness in Gaming one was funny too.
Yeah they love that stuff.
I like the Random Encounter segment. "...You no longer have the egg."