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Grey Renders, chimera and aboleths

Feel free as the GM to modify the ruling in whichever way you feel comfortable. It can be used on any attack, however if you feel vital strike won't apply because a weapon has no anatomy, or if whirlwind attack would just look way too awesome, then just get some feedback from the players and adjust as you see fit.

In addition, all of your attacks made with melee weapons and unarmed strikes are made as if you were two-weapon fighting. Your natural attacks are treated as light, off-hand weapons for determining the penalty to your other attacks. Feats such as Two-Weapon Fighting and Multiattack can reduce these penalties.