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One small detail I love is that the Chalice works with negative healing, because that implement is perfect flavor for a dhampir/vampire character.
Also, assuming you can get an implement and its initiate feature by level 4 or 6 on a multiclassed character, what implements are the best for other classes? Mirror seems phenomenal on a Rogue, allowing you to set up sneak attack by yourself easily. Chalice and Amulet seem good for any front liners with a free hand, notably fighters who don't mind giving up a shield. Tome is a straight upgrade for any Raise a Tome Magus.
It makes me want to play a skeleton pirate thaumaturge and just constantly sip/drink from chalice as stuff just flows over my bones haha.