I'm a new, self-taught player to Pathfinder Adventure and I'm teaching a group of 3 other players. Here are my thoughts:
Card layout: Vast improvement. Sectioned off blocks of information quickly draw your eye to things that matter. I do agree with some others that the card background could be less busy, but the benefit of traits and checks not hanging around with the art and the paragraphical text being narrower and easier to read are huge upsides. It will make picking up the game easier for new players.
Few duplicate cards: It's cool that duplicates are cut down on some cards (bad ones) but I'm not looking forward to being in a game where two players are fighting over a boon and it's the only one in the box. In addition, it seems very unintuitive to use markers for Scourges rather than more physical cards. I guess we'll see in the later blog post just what those markers otherwise do.
Remove When Closed: Seems silly. You get the speed benefit of returning 2-5 entire cards to the box early. There's no chance this was done to "aid clean up". How long does putting away 5 cards that are all going to the same divider take? And this is removing strategic plays from the game. When you're near death, you don't want to be exploring and you don't want to be with people exploring in case they accidentally trip an effect that causes damage to you. This change baffles me.
Card Text: I'm a fan of all the new keywords and using bullet points is a massive improvement, but one thing can be improved still:
Important phases like "Before acting" or "After acting" should be bolded, underlined, or somehow else changed to draw the eye to the text. You should be able to quickly scan a card for relevance, rather than have to read every word. It would speed up game times and decrease mistakes.