SPOILERS - but you probably knew that already -
Let's see. I haven't had a TPK yet, but I am concerned how things may play out in TINH. I started the campaign in Freeport actually (shortly before Savage Tides came out) and had a near TPK in Death in Freeport. All but one pc was killed trying to storm a docked pirate ship with a full crew aboard. I had the Pirate God npc cleric bring them back with the deal that they had to avenge their deaths and bring all loot to the temple for the services provided. They went back and the pirates got toasted and the church got a pirate ship and anything else that was valuable on the ship (including the pirates magic equipment).
Then the party saw a vision of the Pirate God telling them to leave Freeport "that this was not the place for their adventures yet untold" and they went to Sasserine and TINH started. The party rogue pilfered an ornate decanter in Lavinia's parlor while waiting to see her. The party went to the Blue Nixie and I had horrible visions that the TPK was going to happen all over again as they had the same plan in mind (that failed the first time). They tried to broker a deal with the pirates but things went awry and it turned into a slugfest. The rhagodessa made his appearance and almost killed the barbarian-sorcerer if not for party teamwork.
They go to the Vanderboren crypt and Parrot Island and things go by the numbers. While scouting for Lavinia's brother in Sasserine, a child-rogue pickpocketed the party cleric and I did the alley trap with the Lotus Dragons. The barbarian got pissed and immediately killed the pickpocket and the Dragons sniped them from the rooftop. The Dragons snipers all died but they had the clue to go to the Taxidermist Shop next. The party rogue (a clever, nasty fellow) takes the child's corpse in a burlap sack and they go to the shop. Upon entering, the rogue says that he has something he wants stuffed, taking the kid rogue out of the sack, and the party unloads on Roblach and they take him alive (unconscious) back to the Nixie to question him.
Now I want the Dragons to be one step ahead of the party (as they should be) but I am trying to come up with a twist. I figure maybe they should clear out the lair entirely and move into another place before the party comes back for more. Any advice is appreciated along with criticism.