As many have said its an interesting Idea and it can work well to have a defensive roll.
Anima beyond fantasy uses a attack vs defense roll (doge or block) to do it, it causes rounds to go longer, but this also decides the amount of damage things do, better armer effectively raising your defense roll. The game uses d100 to handle the wide range of options.
The whole system has to be geared more towards that type of damaging to be effective. Similarly Damage soak in the form of armor doesnt seem to fit as well with realistic outcomes or the feel of pathfinder/DnD.