Nothing is worse than the 'mobs standing around waiting to be killed'... except the piled high spawn points (think EQ 1, with the lines of cha-cha-ing mobs heading for the exit).
LOTRO and Conan seem to do a decent problem with avoiding (mostly) the 'kill 10 rats' type quests, but there are still too many of them. I'd like to see as many player generated quests as possible, you know?
For me, in particular, with the way I want to play, I'd *love* to see people able to post a 'job' to a board. Something like 'I need 50 brown leathers at the next town over, I'll pay 50s'.
Not just shouted in trade (which gets old), but paying to toss it onto a job board for people like me to load up and bring.