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^this is definately a +1, and a big thanks for doing this by the way!
Ill go ahead and chime in with my own contribution
I created a year long campaign from scratch that fought its ways from the wood of chitterwood, stopping along the way to the isle of absalom, a multiple tiered Tower with different planes of existence all the way to Nex / Geb to search for a PCs missing father, a high level gnomish druid that was part of a druidic council and a pathfinder society member, out to heal the world-wound. This involved extensive back-stories from each player, to tie them into one solid group, but it was and still is one of my favorites. The final BBEG being a ressurrected Lich wizard, that captured the PCs father after an extensive battle. When the lich is destroyed, a summoned Final BBEG Balor Demon(whom the Lich had a pact with) comes forth. Party had 3 rounds to figure out how to stop him if not he would finish the PCs, and resurrect the Lich allowing him to continue his nefarious deeds. To finish it a player, had to willingly sacrifice thier "life" to stop the demon. This was via the phlyactery of the lich and involved swapping in the soul of the pc in place of that of the lich. Finishing the game with a player character becoming the Lich, stopping the final destruction of the PCs, and the Pc's father as well as the whole city of absalom... unless the lich player where to turn on his party, and fight them... I <3 Sandbox + twists. :)
Not sure if this is what you were looking for or not. if you were looking more for quick and dirty ideas... then
Delving into a multi-tiered wizards tower, that traversed multiple planes / places. could be PCs started captured in there and grow slowly as slaves seeking freedom, or as per the usual greedy adventurer, that wishes the archmages treasure horde. Either works really. Could even just be a crazed wizard that issues the challenge to adventures from all of the world to claim a prize so great that no one can help but enter his tower of endless twisted nightmares.
Happy RPG Holidays! :D
TL;DR
More Planar Travel, and multi-tiered gauntlet styled adventuring. :)