Our group (20+ years of gaming together) has had trans, gay, and ambiguously-sexual/gendered members in our group the entire time we've been gaming -- Pathfinder has, without fail, provided a "safe," neutral system for my friends to express themselves without fear of judgement or prejudice. The Anthropologist in me calls out for a more inclusive representation of LGBT characters in the Pathfinder system, but I can't honestly complain about the way this system has represented gender or sexuality in its products -- in general this is a company that provides an "asexual" approach to its products -- thanks, Paizo!!