My first read through Pathfinder was complicated by my experience with 3.x. I focused attention to what was different, and my knowledge of 3.x filled out the rest. I've recently gone back through the book, trying to give incredible focus to every detail. And I'd have to say after an extremely close read, the organization of the CRB is atrocious.
The rules are great once you piecemeal them together from the various sections, charts, and appendices; and in a few places use your imagination to fill in the blanks. For instance, the shield bash rules are in the equipment section, but not in the combat section. Two-weapon fighting is split into at least three sections scattered around the book: two-weapon fighting, off-hand penalties, and the action chart rather than in one place. I read about something earlier in the book only to find expanded rules a few pages later. It makes it hard to read in a linear fashion and even harder to reference. The GM guide is fantastically superior to the D&D products, but makes at least one reference to a chart that doesn't exist in the Paizo books, but does in the DM guide.
So am I for a second edition? You bet. I love these rules and I don't want them to change much, but they need to devote the same level of attention to revising the current rules as they would if they were designing a new product.
And I think they should consider splitting the player's material and the GM material. It seemed like a great value when I first started, but now I'm screaming for a smaller, more focused set of books. My binding is tearing out while having to gopher around this book.