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I'm running this adventure, but have taken some liberties. Firstly, I started my PC's off as slaves from various backgrounds. They were put on the boat that wrecked on the Shiv as newly freed slaves escaping to a better life. I ran through the first book with a minor changes. Gelik said some stuff about slaves that the PC's didn't like and was chased off only to be killed by the cannibals.
My PC's escaped the Shiv and arrived in Eleder. They had a meeting with each faction, and the PC's asked the same question: What was their stance on slavery? Well I stayed on par with each factions, and my PC's didn't like the answers they were given. So I created Spartacus Freemen- Leader of the Freemen Revolt. They have since aligned with him and killed their former slaver boss who was taking bribes from the other factions.
I'm also going my own way to Tazion. I wasn't digging the path that the book wants me to take, so I am home brewing the trip there. I'm still following the outline of the Serpents Skull, but I have 4 people in my group that are veteran gamers, so I have to come up with something to spice the games up. I have a Blade Bound Magus with a sentient sword that has the soul of a capture vampire, and that fits in with the Serpent folk and stuff. Fun stuff.
Since I have added that faction as well, I think it adds another layer to the game.