Just got mine in the mail yesterday, and have only partially digested the content, but figured I'd chime in, as no other reviews have been posted.
I skip around a bit when I first open a copy of Dragon, so I apologize for not ordering my comments by the sequence in which articles appear in the issue.
I really, really enjoyed the meta-humor in the comics.
Class Acts was very solid. I though the Druid option was very flavorful, but didn't take much time to assess the strength of the in game mechanics. The other Class Act sections are natural extensions of ideas introduce in recent supplements (PHB2, Comp. Champion). I think the arcane class variants will probably find immediate use in my next campaign.
The new vestiges are great additions. While I am not involved in a Savage Tide campaign at the moment, the vestiges have universal appeal (at least in regards to binders), but I did have some concerns of the scope of some of the powers. Blasphemy as a supernatural ability in particular seemed powerful, especially in the hands of a well crafted BBEG.
I also liked the tie-ins between this article and the Demonicon of Iggwilv article on Demogorgon.
The Eberron article was quite interesting and has the potential for immediate usage outside of that campaign setting. I've always enjoyed the concept of living spells, so this particular article was a real treat.
Finally, the latest Demonicon of Iggwilv entry rocks. Tons and tons of lore and back-story are crammed into the article, without feeling rushed or overly compressed. I have to admit being lost on occasion when trying to piece together the history and cosmology of the abyss from previous articles or supplements, but the article on Demogorgon brings all of that into focus.
All in all, an excellent issue.