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I believe that the best way to deal with hyper specialized characters is the exact opposite: variety. The character that can deal out the massive damage to one foe gets surrounded by hordes of summoned skeletons. The character that can pass any save gets attacked by the ranged units. The character with the high AC gets spell chucked at them. A single encounter should have more than just one type of foe. And if the players cry foul and that you are cheating by "knowing their character sheets", nobody said you had to stand there and take it. Move, adapt, overcome. That's what my baddies do to them. If my bodyguard is having trouble hitting someone, the boss will use magic. If I see someone that is walking through my skeleton horde, I'll command my bodyguard to shift over and engage that character.
The beauty of this is that if the players use their brains instead of relying on their character's brawn, they will capitalize on their advantages in combat. There is no way a cleric with extra channelings and pumped up turn undead feats wouldn't charge into the middle of a skeleton horde. It's my job to provide the horde, not tell the player to run in there and deal with it.