it's also worth acknowledging that you're changing the assumptions of the AP pretty significantly.
This, and you're also probably changing the setting's assumptions. I've had my share of problems myself with players who like to play against those assumptions as long as I stressed the importance of those assumptions. Then, I've run games where those assumptions where kinda created by playing, and in those kind of games, the problems vanished.
Today, I differentiate between players, who like to play against stereotypes and players of the special snowflake variety. From what I got from this thread, Axial seems to belong in the first category, so I probably wouldn't have any problems with this, even if it meant additional work.
I have to say though, that I don't use the APs or other published adventures as written very much. It's more that I use an adventure's or AP's premise and see what happens if the player characters interact with it (and most of the time, I use those adventures not in the setting, for which they were written anyways). So if an adventure assumes that you don't play option X, but a player expresses the wish to play X anyways, we can make it happen most of the time.
Now if the player is a spotlight hogger, I won't stop him from spotlight hogging by forbidding him to play a certain character, so I'll have to deal with his behavior anyways.