Poison bullets?

[TiwazBlackhand]

I know it's probably not optimal, but is there anything rules wise that would interfere with a gunslinger with the Poisoner archetype poisoning their bullets?

[Cordell Kintner]

Practically speaking, bullets usually come pre-packaged with gunpowder in a cartridge, which allows for the quick reloads of most guns, see the explanation here. You wouldn't really be able to poison the rounds because the paper would interfere with that. You would have to specifically craft bullets with poison on them, before wrapping them in paper, and then hope the explosion of the black powder doesn't destroy the poison when you fire.

Rules wise, there's nothing suggesting you can't I guess?

[aobst128]

Nothing is stopping you RAW wise from poisoning your ammunition. Might take some rationalizing but you could do it. an interesting option for a sniper. Maybe flavor it as a toxic alloy coating you've created for your ammunition.

[Dubious Scholar]

Oh sure, poisoned bullets certainly seem allowed by RAW.

Especially when you read the fluff of Alchemical Shot. I can fire bullets that deal persistent sonic damage, I see no reason applying injury poisons should be an issue!