Depends on how your group likes to run things. If attacks aren't often described it can be just treated as another attack. If attacks are described, you can reflavor the bite as stomping or swiping toward people on the ground instead or getting a flurry of attacks with whatever natural attack would be more likely.
You can split up attacks for other situations, such as if the ant is being flanked it can split its bite to targets near its front and sting others near the back, or sting if it is on the retreat. Though in this option the monsters can some times be less threatening so you can maybe run them as a little higher CR then normal etc.
You can also have the terrain be built for the fight, so the PCs might need to fight the giant from high ground on ramparts or balconies etc where it would be fine to describe bites at them.
From a logical standpoint, a creature of that size would deliver a bite attack after grappling a foe... however you don’t need to perform an actual grapple to accomplish this logical action... you could simply state that it picks the player up and takes a bite at them before releasing them. Mechanical nothing happens besides the bite, RP-wise they are grappled momentarily.
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Combat is not static. Everyone is constantly moving, ducking, weaving.
It is harder to imagine with especially giant monsters like this, but the same principle applies.
The PC's don't just stand around it's feet, stabbing it's ankles until it's dead. They're climbing up it's huge body to hack at it, attacking it's limbs as it reaches out to strike them, running up nearby hills/trees/staircases and jumping off to deliver a blow, etc.
I ran an encounter with a 100ft living hillside in the shape of a person. I completely abandoned regular combat in favor of a sort of moving obstacle course that the characters had to climb and maneuver around. It helped them feel the real scale of the encounter more so than a regular initiative order would ever do.