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I know you can attack with whatever you are holding in your spiked gauntlet, but can you attack with your spiked gauntlet when you're holding a weapon or an item such as a wand?
Weapons: If you're also wielding a weapon in your hand punching with it in your grip wouldn't be different from punching with an Yawara. (In the real world, you'd probably just use the hilt or haft of the weapon quite effectively, but this is Pathfinder and that incurs a penalty/requires feats)
Small Items: Wands (6 to 12 inches long, 0.25 inch thick) are similar in length and a little thinner than Kubotans (5.5 inches long, 0.56 inches thick). One of the defensive moves they teach with a Kubotan is to punch while holding it.

CountofUndolpho |

I think by RAW there is nothing to say you can't use a Gauntlet to attack whilst holding something else. I presume common sense would then be the decider.
Drawing comparisons to RL is fraught with danger as PFRPG is a Fantasy Role Playing Game rather than a replication of RL. Having said that a 1/4" thick wand is Pencil thickness - imagine wearing a metal glove and then punching something hard, hard whilst holding a foot long pencil. I'd treat that like an attempt to break it but I'm mean like that.

Claxon |

To my knowledge there is nothing official about it.
As a house rule, the group I play with we've always said you can use a spike gauntlet while holding a weapon except for two-handed weapons. I guess anything similarly large the required you to hold in two hands would also prevent use. This is mostly because it restricts your range of movement.

BretI |

Still have to wield (as in put the pointy bits out) a Spiked Gauntlet to hit something. That would preclude holding something in that hand.
In general, I wouldn't allow any unarmed strikes with a hand currently holding something.