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The rules state:
Tie-up with rope -- If your opponent is pinned, you may tie them up. Escape DC = 20 + your CMB.
My question is, instead of a rope may I use manacles or something similar? And would the DC still be 20+ your CMB or would it be different?
I see no issue on chaining or using manacles instead or ropes to tie up.
Manacles and mechanical fixations usually have a fixed DC, so you'd use those values instead of any roll.
^ That. For best results, do both! (On different rounds, naturally.)
/but what if they use the manacles to saw through the ropes....
Quickcatch manacles are the item you want. Without them, you cannot do it without gm permission.