
Torbyne |
Spell Combat is a full round action that allows all the attacks you could normally make in a full attack plus a spell so long as you have an open hand to cast the spell, so, yes to point 1.
As for 2, if a spell grants you multiple charges such as frostbite or chill touch, than yes although some may argue over if they can be discharged through three different weapons.
3, If you have a held charge or a spell is allowed to be cast as part of an AoO somehow than you get to spell strike it.
4, Yes, with appropriate penalties for doing so.

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Kasatha have one primary and three offhand.
Ask your GM the multiple two hand gun question and two longswords two handed because that involves pedantic rules ignoring know design decisions. Mainly that "both hands" does not translate to "on primary and on offhand" despite the rules are written from the point of view of a two armed PC.
They can MWF with one longsword two handed and one longswords one handed plus spellcombat. Alternatively three longswords one handed and spell combat.
You can spell strike multiple if you have a spell that allows more than one delivery per round.
If you are holding a charge, on something not limited to a 1/round you can use on AoO.
Two hand gun should look to the ranger archetype for kasatha allowing two guns. If you want multiple one handed guns, then yes apply penalties.

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I would like to point out, as a follow up, that Spell Combat is used much like TWF.
The off hand is the spell, so the weapon is used by the Main Hand. A character/monster only ever has one Main hand to use, all others being Off Hands.
There may be a case where a Longsword can be two handed by the multi-armed creature, but Spell Combat is using the parallel of TWF and only has one weapon and one spell being used.
Now, if Multi-weapon attack is allowed from the Bestiary, which may be a given in your campaign, and the GM allows it, it could be a neat houserule to allow three hands to effect weapon attacks while using Spell Combat. (first level allowing 4 attacks, three weapons and one spell) I am not sure I agree with James on it being able to use it beyond TWF in Rules As Written.