[Setting riff] Y the last man in Golarion and other settings?

[Particle_Man]

In the comic Y the Last Man, all the men just up and die in the same moment, world-wide.

I was wondering what would happen if something a bit like that happened in settings like Golarion (or other settings if you like).

I would change it somewhat and let male animals live. But I would not let male deities or outsiders live.*

So how would the setting deal with the change? Would some divine portfolios go vacant?

*I will say that this means that trans men die and trans women live.