Dirty Tactics Toolbox is out now. In this thread, kindly post neat optimization tricks you've found with this book.
I'll start with Invigorating Poison.
Casting Time 1 standard action
Components V, S, M/DF (an apple seed)
Range touch
Target creature touched
Duration 10 minutes/level
Saving Throw Fortitude negates (harmless); Spell Resistance
yes (harmless)
The body of the target creature gains a metabolic response that
allows it to benefit from normally deadly toxins. When a poison
would cause ability damage to the target creature, the target
instead gains a +4 alchemical bonus to that ability score. The
spell then immediately ends, but the bonus lasts for a number
of minutes equal to the amount of ability damage the poison
would have caused. If the poison would deal more than one
type of ability damage, each bonus has a separate duration.
If the poison has effects other than ability damage (such as
unconsciousness or ability drain), these effects apply normally.
This spell affects only a single poison; if multiple poisons affect
the target simultaneously, this spell prevents only ability
damage and grants the appropriate
This is a long duration pre-buff that gives you an easily stackable +4 to certain ability scores. Sometimes even more than one at once. Familiars and animal companions can inflict a poison on you to save you action economy. Cast this spell on your fighter, and when combat starts, have your compsagnathus familiar bite them to give them a +4 alchemical bonus to strength. Have a Pooka improved familiar? Have her sneeze on you to give you +4 to both wisdom and charisma.
What other tricks have people found with this book?
there's the getting into arcane trickster lv5 as rogue/snakebite brawler 1 wizard 3 with the feat that gives more sneak attack.
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This is a long duration pre-buff that gives you an easily stackable +4 to certain ability scores.
Clarificationon "easily stackable": it's typed as an alchemical bonus so it doesn't stack with itself, but does stack with enhancement bonuses, making it relevant longer than Bull's Strength (etc) and more versatile.