
Claxon |

More importantly, you cannot use a two handed weapon (sized for you) in one hand without a special ability. If that's what your original question is asking.
Technically you can wield a two-handed weapon sized for a size category smaller than you in one hand, but you take the penalty for inappropriately sized weapons.

therealthom |

Just cruised the rules and didn't find anything explicit about using a two-handed weapon in one hand. So RAW back Claxon.
Could you use a two-handed weapon as an improvised one-handed weapon?

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Just cruised the rules and didn't find anything explicit about using a two-handed weapon in one hand. So RAW back Claxon.
Could you use a two-handed weapon as an improvised one-handed weapon?
No.

Gauss |

therealthom, here you go:
Inappropriately Sized Weapons: A creature can’t make optimum use of a weapon that isn’t properly sized for it. A cumulative –2 penalty applies on attack rolls for each size category of difference between the size of its intended wielder and the size of its actual wielder. If the creature isn’t proficient with the weapon, a –4 nonproficiency penalty also applies.
The measure of how much effort it takes to use a weapon (whether the weapon is designated as a light, one-handed, or two-handed weapon for a particular wielder) is altered by one step for each size category of difference between the wielder’s size and the size of the creature for which the weapon was designed. For example, a Small creature would wield a Medium one-handed weapon as a two-handed weapon. If a weapon’s designation would be changed to something other than light, one-handed, or two-handed by this alteration, the creature can’t wield the weapon at all.

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One way to wield a two-handed weapon in one hand is to take three levels of Phalanx Fighter. You must wield a shield in the other hand. This allows you to wield a two handed reach weapon, yet also switch between defensive shield & polearm mode and offensive two-handed-polearm mode as tactical circumstances dictate.