So Furious Focus eliminates the penalty for two handed weapons, had there been any rulings as to whether it applies to monsters with one natural attack (which deals1.5xSTR damage)?
I fail to see the correlation here as this feat is applied to 'one and two-handed weapon' attacks.
The wording of the feat makes it fairly clear that it cannot be applied to a single natural attack: "When you are wielding a two-handed weapon or a one-handed weapon with two hands." I cannot off-hand (no pun intended) think of any creature that has a natural attack that it wields with two hands.
The fact that such an attack uses the same 1.5x STR multiplier for damage is irrelevant.
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While I agree that Furious Focus doesn't apply to Natural Attacks by Raw, I would allow it in my games - only because the wording for Power Attack grants the Natural Weapon user the 3:1 ratio for damage so long as your Natural Attack gives you the 1.5 x STR mod...
But, yeah, by RAW it doesn't apply.