| Trip.H |
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RaW you are correct. Unarmed strikes are never included in the umbrella of weapon strikes. My GM allowed it to work with unarmed when asked though, as the weapon-only restriction makes no sense for the mutagen.
Do note that somewhat recently two new alchemical items were added that do enhance "unarmed strikes," the Iron Wine and Rainbow Vinegar. Adding fire and acid damage. They are not mutagens and work quite differently, but might be what you are looking for.