
Metaphysician |
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I would treat permanent transformations as an Affliction, most likely a Disease. Permanently changing the species of a victim would be its end-state, instead of death. Assuming it isn't purely a plot matter, anyway: if the transformation can only occur voluntarily, or only under circumstances where someone is already dead, then you don't need mechanics, only plot logic.
That said, if the new species they are being transformed into wouldn't be a valid PC race, then I would strongly suggest treating it like death anyway: if the character suddenly gains the equivalent of several levels worth of oomph, they shouldn't remain under the control of the player.