I've never really understood questions like this. It is entirely up to the DM whether or not a single PC could accomplish whatever "goals" might be set.
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I think that if the game balance can be worked out, sure. Any adventure can be. But it's tough to get a single PC who can serve the four classic party roles and still be at a level at which it's at all challenging and fun to play. Adventures are designed with parties of four or more characters in mind, though, so a lot of finagling has to be done on the part of the GM.
Maybe with a really good gestalt...solo really isn't how D&D was designed to be played.
Maybe with a really good gestalt...solo really isn't how D&D was designed to be played.
Sure. Just start the PC at, say, 5th level. He should be about equivalent to a 2nd level party of 4, and since it's 1 PC, you want a cushion there with Paizo's modules.
If you're comfortable with the GM running long-term NPCs, solo games become a lot easier. A pseudodragon with class levels would make a really good party NPC for a solo campaign, I think. The limitations of being Tiny and unable to use weapons (at least, this is how we play them) counterbalance the advantages of being able to fly, DR, high AC and rapid movement, and would certainly make the two characters feel very different in play.
Our pseudodragon PC is a cleric, and I'd recommend that combination: a flying healer is a great resource for keeping PCs alive.
Gestalt fighter/wizard or monk/wizard, plus NPC cleric, could be a viable combination fairly easily, at least through the first couple of modules. It's hard for me to judge the later ones.
Mary