Now what would happen if someone did Treat Disease, when they don’t have any disease?
My players are in a situation where some of them have a disease. The problem is they are at the first stage, which is carrier with no ill effects. Which to me means: They have no symptoms.
Now some of them have the disease, and others don’t. They want to go back to town to do Treat Disease on themselves.
Now looking at the rules for Treat Disease states: “…caring for a diseased creature.”
In addition, the results of Treat Disease all end with: “…saving throw against the disease.”
Which to me means, if they don’t have any disease, then Treat Disease won’t have any effect on them.
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You answered your question. If they don’t have any disease, then Treat Disease won’t have any effect on them, obviously. What else would happen?
If the question is "Can you Treat Disease on someone who doesn't have one", then yes. In this situation they know about the disease, but there's no way for them to know who has it yet, so preventative medicine is a perfectly reasonable reaction.