| BPMasher |
How about combining World of Darkness monster lore with the adventuring lifestyles of Pathfinders into a cohesive whole?
As characters, the different clans and disciplines multiply the options for a Vampire / Werewolf (Gifts etc.) characters and bring a nice breadth of background story (possibly a metaplot involving the Wyrm and Gaia) into the campaign world.
Of course some changes are needed to the abilities, curses/limitations and considerations when playing a shifter character, but it could be managed.
Combine all the personal horror stuff with the alignment system to create truly epic characters. What if Amiri was a werebear who has to keep her bloodline a secret so she won't be hunted down? What if Hayato was also (in addition to being a famous samurai) a Kindred of the East, who has to keep his bloodsucking ways under control?
Lawful Good vampires anyone? I'm envisioning a charismatic Paladin leader, who unfortunately gets drained of blood and Embraced (turned into a vampire) and has to reconcile his bloodsucking ways with his Deity in some grand sacrificial quest. This could become a campaign staple, or even the plot for an entire game.
Just some thoughts off the top of my head.