One of the characters in my campaign may or may not soon contract entothropey/ werespider depending on thr party's actions on our next session. The question I have is would this character, in hybrid form, settle down and say... open an antique shop after trying to murder the party, since that would be at odds with his chaotic neural (borderline evil), adventuring, friend-loving, carefree lifstyle?
entothropy shouldn’t be a method to increase a PC’s power, after all, and what an afflicted entothrope does while in hybrid or vermin form is often at odds with what the character would actually want.
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Entothropy, like Lycanthropy, doesn't simply reverse a character's existing personality. Instead it gives them a second, independent set of drives.
The specifics are up to you, but it seems likely that the werespider would be more sedentary due to web-building instincts. It might not be outright hostile to the character's friends but would certainly lack concern for them. I would also expect a preference for ambush targets.
For more ideas, you could look at the behavior of the werespider from which the PC contracted the curse.