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The format of the Melee entry is:
Melee: The creature's melee attacks are listed here, with its attack roll modifier listed after the attack's name followed by the damage in parentheses.
So each attack causes paralysis, and the bite attack causes disease as well. Saves are required with each attack that hits.
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In a full attack round, imagining they are biting and clawing x 2, does that mean that if a ghoul/ghast succeeds on all 3 attacks the victim should make 3 x paralysis saving throws, + 1 x disease saving throw? ...
Correct. Ghouls are nasty. Fight them from a distance of 15' or more away, so they can't full attack.
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Another note, especially for most first level PCs: Don't go to them, especially in a restricted area. Going one -on-one with a ghoul at low level, when your PC only has one attack, gives the ghoul the action economy.
Some things to remember:
Elves and half-elves are immune to the paralysis effect. They can stoil die form damage taken, however.
A ghoul, having such a high intelligence, can split its attacks among multiple targets, if it so desires. Hit front liner, who fails his save. 5' step forward, do next attack on the next guy in line, maybe both attacks left. See if he fails his save, as well.
I was running an encounter at low level, and the ghoul involved had 4 PCs and an eidolon locked down during most of the combat. Until the half-elf and his friend finally joined the fight. Until then, the ghoul was just doing some small damage while keeping his lunch locked down for later.
On the other hand, they are intelligent, so can possibly be reasoned with. Give a ghoul a reason to not want to kill you and it could even help you, depending on the incentive given and the nature of the situation.